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EP400 (12q24) gene breakage probe reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501044Ⅰ-01/R-0501044Ⅰ-02/R-0501044Ⅱ-01/R-0501044Ⅱ-02/R-0501044Ⅲ-01/R-0501044Ⅲ-02/R-0501044Ⅳ-01/R-0501044Ⅳ-02
Probe name:GSP EP400(Centromere)/ GSP EP400(Telomere)
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

A fusion of the EP400 (12q24) gene with the PHF1 gene is seen in ossifying fibromucinous tumors and is used as an aid to diagnosis. MEAF6-PHF1 and EPC1-PHF1 fusions are also seen in this tumor and can be detected with a PHF1 breakthrough probe (total positivity rate of 50%-80%). It may also be accompanied by a small number of ZC3H7B-BCOR, CREBBP-BCORL1 and KDM2A-WWTR1 fusions.


It is primarily distinguished from soft tissue myoepithelioma and extraosseous myxoid chondrosarcoma. Extraosseous myxoid chondrosarcoma is characterized by the t(9;22) translocation, forming the EWSR1-NR4A3 fusion gene (occurrence rate 50%–70%), as well as variant forms of NR4A3 fusions with other genes. NR4A3 breakpoint probes can be used to assist in diagnosis.