Fibroblastic/myofibroblastic tumors and verrucous lesions

Application to Infantile Fibrosarcoma (Infantile Fibrosarcoma);

Most studies have found that Infantile Fibrosarcoma presents with a t(12;15)(p13;q25) abnormality (incidence 75% to 90%), which results in a fusion of the ETV6 (TEL) gene with the NTRK3 (TRKC) gene ;

The differential diagnosis of infantile fibrosarcoma includes infantile myofibrosarcoma, compound fibromatosis, rhabdomyosarcoma, spindle cell adenovesicular rhabdomyosarcoma, infantile rhabdomyosarcoma, and renal primitive mucinous-like mesenchymal cell tumors;

It has been newly discovered that LMNA-NTRK1 fusion can also be present in a small percentage of infantile myofibroblastic tumors, suggesting that the relationship between this tumor and infantile fibrosarcoma still needs to be The relationship between this tumor and infantile fibrosarcoma remains to be determined.

Myelodysplastic syndromes

detects breaks and fusions of ETV6(TEL) with other genes.

Acute Lymphoblastic Leukemia (ALL)

ETV6(TEL) can be tested for breaks and fusions with other genes.