30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)

30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)
Rhabdomyosarcoma (RMS) is a common malignancy among soft tissue tumors in children, and the prognosis is related to the primary site of the tumor, pathological staging, and the extent of the lesion (stage). The prognosis of vesicular and pleomorphic tumors is poor, and the prognosis of embryonal tumors is moderate.
Specific chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are detected in 70% to 80% of adenoid rhabdomyosarcomas (ARMS), and the two translocations form the corresponding fusion genes PAX3-FKHR (about 75%) and PAX7-FKHR (about 25%), respectively; these two chromosomal translocations are not seen in embryonal rhabdomyosarcomas. these two chromosomal translocations.
In addition, it is difficult to perform the differentiation of ARMS from some small round cell tumors by histological analysis; therefore, FKHR (FOXO1) rearrangement detection is beneficial for the typing of rhabdomyosarcoma.