30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)

30006000330066003300660036007200
5T/box(Ⅰ-01)10T/box(Ⅰ-02)5T/box(Ⅱ-01)10T/box(Ⅱ-02)5T/box(Ⅲ-01)10T/box(Ⅲ-02)5T/box(Ⅳ-01)10T/box (IV-02)
Chronic granulocytic leukemia (CML)
JAK2 is a tyrosine kinase, and the JAK /STAT signaling pathway plays an important role in the proliferation and differentiation of hematopoietic stem cells;
Ph(-)MPDs are characterized by somatic JAK2 gene mutations and gene recombination;
It can assist in the diagnosis of chronic myeloproliferative disorders, as well as guide the treatment and prognosis.
Ph-like ALL
JAK gene translocations are seen in about 7.4% of Ph-like ALL, with JAK2 translocations being particularly common. The translocations usually retain the kinase domain of the JAK gene and a fusion protein is formed;
JAK2 has a variety of partner genes, and these translocations lead to sustained cell proliferation by activating the JAK-STAT signaling pathway.