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JAK2 (9p24) gene breakage probe reagent
Wholesale Price(RMB):

30006000330066003300660036007200

Product Code:R-0501246Ⅰ-01/R-0501246Ⅰ-02/R-0501246Ⅱ-01/R-0501246Ⅱ-02/R-0501246Ⅲ-01/R-0501246Ⅲ-02/R-0501246Ⅳ-01/R-0501246Ⅳ-02
Probe name:GSP JAK2(Centromere)/ GSP JAK2(Telomere)
Product Code:Type I (direct FISH method)/Type II (biotin-labeled indirect FISH method)/Type III (digoxigenin-labeled indirect FISH method)/Type IV (TSA-FISH method)
Registration Number:
Clinical Value

Chronic granulocytic leukemia (CML)

JAK2 is a tyrosine kinase, and the JAK /STAT signaling pathway plays an important role in the proliferation and differentiation of hematopoietic stem cells;

Ph(-)MPDs are characterized by somatic JAK2 gene mutations and gene recombination;

It can assist in the diagnosis of chronic myeloproliferative disorders, as well as guide the treatment and prognosis.


Ph-like ALL

JAK gene translocations are seen in about 7.4% of Ph-like ALL, with JAK2 translocations being particularly common. The translocations usually retain the kinase domain of the JAK gene and a fusion protein is formed;

JAK2 has a variety of partner genes, and these translocations lead to sustained cell proliferation by activating the JAK-STAT signaling pathway.