CD42b Molecular Targets Information Overview

Molecular Name: Platelet Glycoprotein Ib alpha chain (GPIbα)

Gene Family: mucins family

Synonyms: GPIBA, GP1BA, GPIb-alpha, CD42b-alpha, BSS (Bernard- Soulier syndrome associated name)

Formerly known as: GP-Ib alpha, VWDP

Overview of the molecular targets of CD42b

has a molecular weight of 145 kD and is expressed on platelets and megakaryocytes. It belongs to the mucin (mucins) family, and its ligands and related molecules are: vWF, thrombin and snake venom proteins.

CD42b forms platelet GPⅠbα/Ⅸ complex with GPⅨ, CD42b/CD42a. CD42b complexes CD42b/CD42a, CD42b/CD42c and CD42b/CD42d are the main receptors for vWF and are associated with vascular endothelial injury surface and platelet adhesion and platelet-plasmin interaction.

CD42b expression is reduced on platelets from patients with Bernard-Soulier disease (hereditary GP Ibα/Ⅸ deficiency) and positively expressed on platelets from patients with pro-macrocyte/megakaryocyte leukemia cells (acute myelogenous leukemia type M7), thus CD42b can be used in Bernard-Soulier disease (hereditary GP Ibα/Ⅸ deficiency) and promyelocytic/megakaryocytic leukemia type M7.